Mapping brain gases to understand brain function loss
Official title: Obtaining brain pCO2, pH and pO2 maps via measurements of neurovascular coupling: a novel non-invasive approach to identify the culprits of loss of brain function
Funded at University of Minnesota · NIH-10924718 · Data updated 2026-11-12
This study is looking at how blood flow and brain activity work together to keep our brains healthy, and it's trying to create new ways to safely measure important substances in the brain, which could help improve how we understand brain function and develop better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,078,000 |
| NIH project number | 1DP1AG093028-01 |
| Project ID | NIH-10924718 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing neurological conditions that affect brain function, such as stroke or neurodegenerative diseases.
✕Less likely to help
Patients with stable neurological conditions or those not experiencing any cognitive or functional impairments may not benefit from this research.
What this research studies
This research investigates how the relationship between cerebral blood flow and neuronal activity affects brain function. It aims to develop new non-invasive imaging techniques to measure levels of carbon dioxide and protons in the brain, which are crucial for maintaining metabolic balance. By understanding these dynamics, the research seeks to provide insights into the mechanisms behind brain function loss and improve the interpretation of existing imaging methods like fMRI. Patients may benefit from advancements in diagnostic techniques and potential new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of conditions associated with brain function loss.
How similar studies have gone: While the approach of mapping brain gases is innovative, similar research has shown promise in understanding neurovascular coupling and brain metabolism.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Mangia, Silvia — University of Minnesota
- Study coordinator: Mangia, Silvia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.