How regular cash support during adulthood affects memory and dementia risk in rural South Africa

Cumulative socioeconomic exposures, cash transfer interventions, and later-life cognitive decline and dementia risk in a low-income region of South Africa

NIH-funded research Trustees of Indiana University · NIH-11379399

This work looks at whether receiving government cash payments during adulthood helps protect memory and lower the chance of dementia for people in a low-income region of South Africa.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionTrustees of Indiana University NIH-funded
Lab location1 site (Bloomington, United States)
Project IDNIH-11379399 on NIH RePORTER

What this research studies

You would be part of research that combines long-running local population records, an aging cohort, and data from randomized cash transfer programs to see how money people receive across their lives relates to later memory and dementia. The team links individuals across a regional census, an adult aging study (HAALSI), and a prior randomized cash transfer trial to follow cognitive outcomes over time. They will study different amounts, lengths of time receiving payments, and which ages or groups benefit most to find the best ways cash transfers might protect the brain. The goal is to produce evidence that policymakers can use to design social programs that reduce dementia risk.

Who could benefit from this research

Good fit: Adults living in the low-income rural regions of South Africa covered by the linked cohorts, especially those who have received or could receive government cash transfer payments, are the ideal participants.

Not a fit: People who live outside the study region or whose cognitive problems are driven mainly by non-social causes (for example certain genetic conditions) may not directly benefit from these program-focused findings.

Why it matters

Potential benefit: If successful, the findings could guide cash transfer program designs that reduce memory decline and lower dementia risk for many people in low-income settings.

How similar studies have performed: Earlier work by this team found that randomized cash transfers were linked to better later-life memory and lower dementia probability, so this project builds on promising prior results to find the best program designs.

Where this research is happening

Bloomington, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementia
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.