Learning Precision Medicine for Rare Diseases with Data Mining
Official title: Learning Precision Medicine for Rare Diseases Empowered by Knowledge-driven Data Mining
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11384758 · Data updated 2026-11-12
Aimed at speeding up diagnosis for people with rare diseases by building a knowledge-led data mining framework that helps clinicians access up-to-date information.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 6, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $703,471 |
| NIH project number | 5R01HG012748-04 |
| Project ID | NIH-11384758 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with suspected or confirmed rare diseases, whose diagnosis is often delayed, may benefit from faster, more informed clinical decision-making.
✕Less likely to help
Patients without rare diseases or with already clear diagnoses may not directly benefit from this diagnostic-speed initiative.
What this research studies
This project creates RDAccelerate, a computable knowledge hub that aggregates current findings on rare diseases so doctors can quickly find relevant information. It partners with Mayo Clinic PRaUD and Vanderbilt to translate the latest research into clinical practice. The team will build an end-to-end informatics framework to support faster, more accurate diagnoses for patients with uncommon conditions.
Why it matters
Potential benefit: If successful, it could shorten the time to diagnosis and improve care for people with rare diseases.
How similar studies have gone: Other knowledge-translation and informatics efforts have shown promise in accelerating diagnosis, though this specific integrated hub is a novel approach.
Where this research is happening
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University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Liu, Hongfang — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Liu, Hongfang
Related research
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Liver pathobiology from rare liver diseases
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Data Management and Coordinating Center support for Rare Diseases Research
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EEG-based drug repurposing for rare CNS diseases
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Ethics of Engaging Patient Groups in Drug Development for Rare Diseases
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Center for Polyamine Disorders group study of rare metabolic disorders
A research consortium is studying a group of rare metabolic disorders linked to polyamines and aims to understand symptoms, biomarkers, and disease progression to improve care.
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Encore: speeding up finding new uses for existing drugs to help kids with rare diseases
A big NIH project will test thousands of existing medicines to see if any can help treat rare genetic diseases in children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.