Center for Polyamine Disorders group study of rare metabolic disorders
Official title: The Center for Polyamine Disorders (CPD) Consortium of the Rare Diseases Clinical Research Network (RDCRN)
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-11453331 · Data updated 2026-11-12
A research consortium is studying a group of rare metabolic disorders linked to polyamines and aims to understand symptoms, biomarkers, and disease progression to improve care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 8, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,657,037 |
| NIH project number | 1U54HD122910-01 |
| Project ID | NIH-11453331 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with polyamine pathway-related disorders such as SMS deficiency, BABS, DHPS/DOHH deficiencies, or FABAS, identified through clinical care or prior research networks.
✕Less likely to help
Early-stage observational studies may not immediately change care for all participants.
What this research studies
This program brings together multiple centers to observe people with polyamine-related disorders over time, collecting clinical data to map how these conditions present and change. Researchers will develop and validate laboratory tests and biomarkers that reflect disease activity and help track patient status. The effort builds on previous work with specific syndromes and uses collaboration to gather comprehensive information across affected individuals.
Why it matters
Potential benefit: If successful, patients could see earlier diagnosis, better monitoring, and new biomarkers that guide personalized treatment in polyamine disorders.
How similar studies have gone: Previous studies showed meaningful insights in SRS and BABS with biomarker and clinical data integration, supporting potential benefit of expanded longitudinal studies.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Bachmann, Andre S — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Bachmann, Andre S
Related research
Other NIH-funded projects on the same topics.
-
Liver pathobiology from rare liver diseases
A study at UCSF looks at why rare liver conditions cause liver damage, with the aim of finding new ways to diagnose and treat chronic liver disease.
-
Data Management and Coordinating Center support for Rare Diseases Research
A national rare diseases research program is funding a center to manage data and coordinate studies to help improve diagnosis, care, and potential treatments for children with rare conditions.
-
EEG-based drug repurposing for rare CNS diseases
A new approach uses EEG brain signatures to find existing drugs that might help people with rare nervous-system disorders.
-
Ethics of Engaging Patient Groups in Drug Development for Rare Diseases
This grant asks how patient and family groups can ethically help shape rare-disease drug development from idea to market, with input from patients, families, doctors, and researchers.
-
Encore: speeding up finding new uses for existing drugs to help kids with rare diseases
A big NIH project will test thousands of existing medicines to see if any can help treat rare genetic diseases in children.
-
Advancing Craniosynostosis Care: Pilot/Feasibility Governance Core
A pilot and governance program to speed up practical ideas for better care for children with syndromic craniosynostosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.