Latino aging and brain health: a population study on Alzheimer's risk
Official title: A Population-Based Risk Study of Alzheimer’s Disease
Funded at Rush University Medical Center · NIH-11416734 · Data updated 2026-11-12
A large study in older Latino adults will follow participants in Chicago to understand what affects the risk and progression of Alzheimer’s disease and related dementias in this group.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,052,948 |
| NIH project number | 5UH3AG083289-04 |
| Project ID | NIH-11416734 on NIH RePORTER |
Who could benefit from this research
✓Could help
Latino adults aged 65 and older (and potentially at-risk individuals) willing to participate in a longitudinal cohort with neurological assessments and genetic testing.
✕Less likely to help
Individuals without interest or eligibility for longitudinal participation or genetic testing may not directly benefit.
What this research studies
This project builds a community-focused Latino cohort in Chicago to study how factors like cardiovascular health, inflammation, and genetics (including APOE4) relate to dementia risk. Researchers will establish infrastructure, engage with local communities, and create a plan for sharing resources with researchers and participants. They will conduct neurological assessments in about 300 Latino adults to see how common Alzheimer’s-related conditions are and whether APOE4 affects risk similarly to non-Hispanic White individuals. The study aims to translate findings into tailored prevention and care approaches for Latino communities.
Why it matters
Potential benefit: If successful, the study could lead to earlier identification and culturally appropriate prevention strategies for Alzheimer’s and related dementias in Latino populations.
How similar studies have gone: Previous studies show APOE4 and cardiovascular factors influence dementia risk, but population-specific data for Latinos is limited, making this study relatively novel.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Rajan, Kumar B. — Rush University Medical Center
- Study coordinator: Rajan, Kumar B.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.