Kidney support for babies and kids using a small, low-blood-volume CRRT device
Official title: Kidney Support in Pediatric Patients using an Ultrafiltration Device
Funded at Koronis Biomedical Technologies Corporat · NIH-11408830 · Data updated 2026-11-12
A new CRRT device called Vivian aims to help critically ill pediatric and neonatal patients with kidney problems by using an ultrafiltration system that works well for small bodies.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Koronis Biomedical Technologies Corporat NIH-funded |
| Lab location | 1 site (Minneapolis, UNITED STATES) |
| Project start | May 18, 2021 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,099,700 |
| NIH project number | 5R44DK127631-05 |
| Project ID | NIH-11408830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are neonates and children with acute kidney injury or severe fluid overload who require CRRT.
✕Less likely to help
Very small or unstable patients for whom CRRT is not appropriate may not benefit.
What this research studies
This grant supports bringing Vivian, a continuous renal replacement therapy platform, to market for treating sick babies and children with acute kidney injury and fluid overload. The approach focuses on reducing the blood volume required for treatment, which is crucial for very small patients. The project includes development and testing in clinical settings to ensure safety and effectiveness for pediatric and neonatal use.
Why it matters
Potential benefit: If successful, Vivian could reduce treatment risks and improve survival and recovery for sick children with kidney failure.
How similar studies have gone: Previous CRRT devices have faced limitations with extracorporeal blood volume; this project aims to overcome that with ultrafiltration-based design, which is promising but requires confirmation.
Where this research is happening
-
Koronis Biomedical Technologies Corporat
Minneapolis, United States Active
Researchers
- Principal investigator: Knuesel, Robert J — Koronis Biomedical Technologies Corporat
- Study coordinator: Knuesel, Robert J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.