Low‑volume kidney support for newborns and young children
Kidney Support in Pediatric Patients using an Ultrafiltration Device
This project is bringing a new low‑blood‑volume dialysis device to help newborns and small children with sudden kidney failure or dangerous fluid overload.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Koronis Biomedical Technologies Corporat NIH-funded |
| Lab location | 1 site (Minneapolis, UNITED STATES) |
| Project ID | NIH-11256219 on NIH RePORTER |
What this research studies
This effort aims to deliver a pediatric Continuous Renal Replacement Therapy machine called Vivian that uses ultrafiltration and a much smaller extracorporeal blood volume than current systems. Because babies and neonates have very small total blood volume, the smaller circuit is meant to reduce the risk of complications during dialysis. The company and its manufacturing partner will complete device development, perform safety and performance testing, and prepare for clinical use and regulatory approval. If successful, hospitals could start using the device in neonatal and pediatric intensive care units.
Who could benefit from this research
Good fit: Newborns, premature infants, and young children with acute kidney injury or severe fluid overload who need continuous renal replacement therapy are the ideal candidates.
Not a fit: Patients who do not require CRRT, older children or adults who are too large for a pediatric device, or those with conditions better treated by other kidney therapies may not benefit from this pediatric‑focused device.
Why it matters
Potential benefit: Could make dialysis safer and more feasible for newborns and very small children by lowering the amount of blood outside the body and reducing complications.
How similar studies have performed: Adult CRRT machines are well established, but commercial devices specifically designed with extra‑low extracorporeal blood volume for neonates are limited, so this represents a relatively novel pediatric device development.
Where this research is happening
Minneapolis, UNITED STATES
- Koronis Biomedical Technologies Corporat — Minneapolis, United States (Active)
Researchers
- Principal investigator: Knuesel, Robert J — Koronis Biomedical Technologies Corporat
- Study coordinator: Knuesel, Robert J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.