Low‑volume kidney support for newborns and young children
Official title: Kidney Support in Pediatric Patients using an Ultrafiltration Device
Funded at Koronis Biomedical Technologies Corporat · NIH-11256219 · Data updated 2026-11-12
This project is bringing a new low‑blood‑volume dialysis device to help newborns and small children with sudden kidney failure or dangerous fluid overload.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Koronis Biomedical Technologies Corporat NIH-funded |
| Lab location | 1 site (Minneapolis, UNITED STATES) |
| Project start | May 18, 2021 |
| Project end | July 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,100,003 |
| NIH project number | 2R44DK127631-04 |
| Project ID | NIH-11256219 on NIH RePORTER |
Who could benefit from this research
✓Could help
Newborns, premature infants, and young children with acute kidney injury or severe fluid overload who need continuous renal replacement therapy are the ideal candidates.
✕Less likely to help
Patients who do not require CRRT, older children or adults who are too large for a pediatric device, or those with conditions better treated by other kidney therapies may not benefit from this pediatric‑focused device.
What this research studies
This effort aims to deliver a pediatric Continuous Renal Replacement Therapy machine called Vivian that uses ultrafiltration and a much smaller extracorporeal blood volume than current systems. Because babies and neonates have very small total blood volume, the smaller circuit is meant to reduce the risk of complications during dialysis. The company and its manufacturing partner will complete device development, perform safety and performance testing, and prepare for clinical use and regulatory approval. If successful, hospitals could start using the device in neonatal and pediatric intensive care units.
Why it matters
Potential benefit: Could make dialysis safer and more feasible for newborns and very small children by lowering the amount of blood outside the body and reducing complications.
How similar studies have gone: Adult CRRT machines are well established, but commercial devices specifically designed with extra‑low extracorporeal blood volume for neonates are limited, so this represents a relatively novel pediatric device development.
Where this research is happening
-
Koronis Biomedical Technologies Corporat
Minneapolis, United States Active
Researchers
- Principal investigator: Knuesel, Robert J — Koronis Biomedical Technologies Corporat
- Study coordinator: Knuesel, Robert J
Related research
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Kidney support for babies and kids using a small, low-blood-volume CRRT device
A new CRRT device called Vivian aims to help critically ill pediatric and neonatal patients with kidney problems by using an ultrafiltration system that works well for small bodies.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.