Keeping mitochondria working properly
Mitochondrial Fidelity and Homeostasis
This project looks at how cells keep mitochondria healthy to help prevent or treat conditions like ALS, Parkinsonism, heart problems, and some cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project ID | NIH-11324522 on NIH RePORTER |
What this research studies
From a patient perspective, scientists are studying the cellular systems that maintain mitochondrial protein folding, assembly, and membrane integrity so mitochondria can keep cells alive and working. They use a range of laboratory approaches across model systems to map conserved quality-control mechanisms and how those mechanisms respond to stress. The team links these basic processes to human disorders such as ALS, neuropathies, Parkinsonism, hearing loss, certain dementias, heart disease, and some cancers. Researchers aim to learn how to manipulate these mechanisms to eventually guide new treatments that protect vulnerable cells.
Who could benefit from this research
Good fit: People with conditions tied to mitochondrial dysfunction—for example ALS, certain neuropathies, Parkinsonism, mitochondrial-related heart disease, or related dementias—would be most relevant for participation or future trials.
Not a fit: Patients whose illnesses are unrelated to mitochondrial biology or who need immediate clinical treatments are unlikely to see direct benefits from this basic research in the short term.
Why it matters
Potential benefit: If successful, this work could reveal ways to protect nerve, heart, and other cells from degeneration and point to new therapeutic strategies for mitochondrial-related diseases.
How similar studies have performed: Researchers have identified important mitochondrial quality-control pathways before, but turning those findings into reliable clinical treatments remains largely unproven.
Where this research is happening
Lincoln, United States
- University of Nebraska Lincoln — Lincoln, United States (Active)
Researchers
- Principal investigator: Khalimonchuk, Oleh — University of Nebraska Lincoln
- Study coordinator: Khalimonchuk, Oleh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.