Investigating the genetic factors of severe alcohol use disorder
A Genome Wide Association Study of Severe Alcohol Use Disorder
This study is looking at the genes that might make some people more likely to struggle with severe alcohol use disorder, and it's for anyone who has this condition and wants to help researchers find better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10457001 on NIH RePORTER |
What this research studies
This research aims to understand the genetic basis of severe Alcohol Use Disorder (AUD) by conducting a genome-wide association study (GWAS) involving 12,000 well-characterized cases. By analyzing genetic data, the study seeks to identify specific genetic variants that contribute to the risk of developing AUD and its associated mental health conditions. Patients will be assessed for complete DSM-5 criteria for AUD, along with co-morbidities such as depression and antisocial personality disorder. The findings could lead to better understanding and potential new treatments for AUD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with severe Alcohol Use Disorder as defined by DSM-5 criteria.
Not a fit: Patients with mild or moderate alcohol use disorder may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for individuals suffering from severe alcohol use disorder.
How similar studies have performed: Previous genome-wide association studies have shown success in identifying genetic factors for various complex disorders, suggesting that this approach could yield valuable insights for AUD as well.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Kendler, Kenneth Seedman — Virginia Commonwealth University
- Study coordinator: Kendler, Kenneth Seedman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.