Investigating mitochondrial genetic differences in human tissues
Official title: Mitochondrial Genetic Variation Across Human Tissues
Funded at Boston University Medical Campus · NIH-10911342 · Data updated 2026-11-12
This study is looking at how differences in the genetic material found in our cells might play a role in diseases that affect both kids and older adults, by examining tissue samples to see how these variations change with age and in different parts of the body.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $82,500 |
| NIH project number | 5R03AG081053-02 |
| Project ID | NIH-10911342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with mitochondrial diseases or those interested in the genetic factors influencing aging and tissue health.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or those who are not within the age range of interest may not benefit from this research.
What this research studies
This research explores how variations in mitochondrial DNA (mtDNA) across different tissues in the human body may contribute to various diseases, including those that affect children and aging adults. By analyzing genetic data from a large dataset of postmortem tissue samples, the study aims to identify the presence and frequency of different mtDNA variants in various tissues. The researchers will utilize advanced sequencing techniques to understand how these genetic differences may relate to age and tissue type, potentially revealing important insights into mitochondrial diseases.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for mitochondrial diseases and age-related conditions.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial genetics, but this specific approach of comparing tissue variants across a large population is relatively novel.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Fetterman, Jessica L — Boston University Medical Campus
- Study coordinator: Fetterman, Jessica L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.