Investigating low-intensity focused ultrasound for treating anxiety and pain in patients with opioid use disorder.
Towards treatment for the complex patient: investigations of low-intensity focused ultrasound.
This study is looking at a gentle ultrasound treatment that might help people dealing with opioid use disorder, chronic pain, and anxiety by calming down a specific part of the brain, and it’s for anyone who wants to explore new ways to feel better without invasive procedures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Clinical Research, INC. NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10775216 on NIH RePORTER |
What this research studies
This research explores the use of low-intensity focused ultrasound (LIFU) as a noninvasive treatment for patients suffering from opioid use disorder, chronic pain, and anxiety. By targeting a specific brain region known as the anterior insula, the study aims to reduce symptoms associated with these interconnected conditions. Participants will receive one session of LIFU, which is designed to inhibit overactive brain activity linked to pain and anxiety, potentially leading to improved treatment outcomes. The study will compare the effects of LIFU against a sham treatment to ensure safety and efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with opioid use disorder who also experience chronic pain and anxiety disorders such as generalized anxiety disorder, post-traumatic stress disorder, or social anxiety disorder.
Not a fit: Patients who do not have opioid use disorder or do not experience chronic pain and anxiety may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, noninvasive treatment option for patients struggling with the complex interplay of opioid use disorder, chronic pain, and anxiety.
How similar studies have performed: While the use of LIFU is a relatively novel approach, preliminary studies in related areas suggest potential for success in treating similar conditions.
Where this research is happening
Washington, United States
- Institute for Clinical Research, INC. — Washington, United States (Active)
Researchers
- Principal investigator: Lee, Mary — Institute for Clinical Research, INC.
- Study coordinator: Lee, Mary
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.