Investigating how unique human genetic features influence brain development and signaling pathways
Official title: Roles for uniquely human enhancers in brain development and WNT signaling
Funded at Duke University · NIH-11010394 · Data updated 2026-11-12
This study is looking at special parts of our DNA that make us human and how they help shape our brains, especially in areas linked to growth and function, to better understand their connection to brain conditions like autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | March 9, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $551,344 |
| NIH project number | 5R01MH132089-03 |
| Project ID | NIH-11010394 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with autism spectrum disorder or other neurodevelopmental conditions.
✕Less likely to help
Patients with neurological conditions unrelated to genetic factors or those without developmental disorders may not receive benefit from this research.
What this research studies
This research explores the role of specific genetic regions that are unique to humans in the development of the brain, particularly focusing on the cerebral cortex. It examines how these genetic elements, known as human accelerated regions (HARs), affect the expression of genes involved in brain growth and function. By using mouse models that mimic human genetic traits, the study aims to uncover the biological functions of these HARs and their association with neurological disorders, potentially leading to insights into conditions like autism spectrum disorder.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain development and lead to new therapeutic strategies for neurological disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of genetic factors in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Silver, Debra — Duke University
- Study coordinator: Silver, Debra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.