Investigating how two specific chemokines interact and affect diseases like atherosclerosis and autoimmune disorders.
Official title: The biological effect and the mode of action of the CXCL7-CXCL12 chemokine heterodimer
Funded at University of North Carolina Charlotte · NIH-10730914 · Data updated 2026-11-12
This study is looking at how two important proteins, CXCL7 and CXCL12, work together and affect how cells move and respond in the body, with the goal of finding better treatments for people with heart and autoimmune diseases.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Carolina Charlotte NIH-funded |
| Lab location | 1 site (Charlotte, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $462,000 |
| NIH project number | 1R15CA283775-01 |
| Project ID | NIH-10730914 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from atherosclerosis or autoimmune disorders.
✕Less likely to help
Patients with conditions unrelated to chemokine interactions or those not affected by atherosclerosis or autoimmune diseases may not benefit from this research.
What this research studies
This research explores the interactions between two chemokines, CXCL7 and CXCL12, which are important in various health conditions, including atherosclerosis and autoimmune diseases. The study aims to understand how these chemokines form a heterodimer and the biological effects of this interaction on cell migration and immune responses. By examining how these chemokines activate their receptors, the research seeks to uncover new therapeutic strategies that could improve treatment options for patients with related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the treatment of atherosclerosis and autoimmune diseases.
How similar studies have gone: While the specific interactions of CXCL7 and CXCL12 are being explored in this research, similar studies on chemokine interactions have shown promise in understanding immune responses and developing new treatments.
Where this research is happening
-
University of North Carolina Charlotte
Charlotte, United States Active
Researchers
- Principal investigator: Nesmelov, Yuri — University of North Carolina Charlotte
- Study coordinator: Nesmelov, Yuri
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.