Investigating how T cells can function over multiple lifetimes
Using an in vivo multi-lifetime model to test mechanisms of aging
This study is looking at how certain immune cells in mice can stay strong and active for over 11 years, which might help us learn more about aging and how to keep our immune systems healthy as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10856475 on NIH RePORTER |
What this research studies
This research explores the mechanisms behind the longevity of T cells in mice, which can be boosted and maintained for over 11 years. By studying these cells, the researchers aim to understand how they retain their functionality and proliferative capacity without undergoing uncontrolled division. The project involves multiple cohorts of T cells that have been subjected to various boosts over time, allowing for a detailed analysis of their behavior and adaptations in a young host environment. This could provide insights into cellular aging and longevity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of aging and immune function, particularly those with age-related health concerns.
Not a fit: Patients with acute or severe immune deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in extending the functional lifespan of immune cells, potentially improving treatments for age-related diseases.
How similar studies have performed: Other research has shown promising results in understanding cellular aging, but this specific approach of studying multi-lifetime T cells is relatively novel.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Masopust, David — University of Minnesota
- Study coordinator: Masopust, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.