Investigating how stress affects the aging brain using advanced imaging techniques
Official title: Stress and aging: longitudinal evaluation of synaptic changes using in vivo SV2A PET
Funded at Yale University · NIH-11136094 · Data updated 2026-11-12
This study is looking at how stress affects the aging brain using special imaging techniques, and it's designed for anyone interested in understanding how stress might impact memory and mental health as we get older.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $127,386 |
| NIH project number | 1K01AG090892-01A1 |
| Project ID | NIH-11136094 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing stress-related cognitive issues or those interested in the effects of stress on brain health.
✕Less likely to help
Patients who are not experiencing stress or age-related cognitive decline may not benefit from this research.
What this research studies
This research focuses on understanding the impact of stress on the aging brain by utilizing in vivo Positron Emission Tomography (PET) imaging techniques. It aims to evaluate synaptic changes over time in animal models that experience chronic stress, providing insights into the biological processes associated with aging. The study will involve rigorous training in various methodologies, including molecular and behavioral assessments, to ensure a comprehensive approach to the research. By bridging basic science with clinical applications, the findings could enhance our understanding of age-related cognitive decline and mental health issues.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing stress-related cognitive decline in aging populations.
How similar studies have gone: Previous research has shown promising results using PET imaging to study brain changes, indicating that this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Asch, Ruth H. — Yale University
- Study coordinator: Asch, Ruth H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.