Investigating how specific proteins affect brain function and memory.
Official title: Protein phosphatase 1 isoforms, human de novo mutations and synaptic functions
Funded at University of Rochester · NIH-11031399 · Data updated 2026-11-12
This study is looking at how different types of a protein called PP1 affect memory and brain communication in mice, which could help us understand memory problems and find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | March 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $488,733 |
| NIH project number | 5R01MH128279-03 |
| Project ID | NIH-11031399 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cognitive deficits or those at risk for degenerative brain diseases.
✕Less likely to help
Patients with cognitive impairments not related to the mechanisms being studied may not benefit from this research.
What this research studies
This research explores the roles of different protein phosphatase 1 (PP1) isoforms in brain functions such as memory and synaptic transmission. By using advanced mouse models, the study aims to understand how these proteins influence the formation and communication of synapses, which are crucial for cognitive processes. The researchers will examine how specific interactions between these proteins and other cellular components affect brain activity and memory formation. This could lead to insights into cognitive deficits and potential therapeutic targets for related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cognitive deficits and degenerative diseases affecting memory and brain function.
How similar studies have gone: Previous research has shown promising results in understanding the roles of protein phosphatases in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Xia, Houhui — University of Rochester
- Study coordinator: Xia, Houhui
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.