Investigating how specific proteins affect brain cell communication and memory.
Official title: Protein phosphatase 1 isoforms, human de novo mutations and synaptic functions
Funded at University of Rochester · NIH-11263480 · Data updated 2026-11-12
This study is looking at how different types of a protein called PP1 affect brain cell activities, especially how nerve cells communicate and help with memory, using special mouse models to learn more about their role in brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | March 1, 2025 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $38,123 |
| NIH project number | 3R01MH128279-03S1 |
| Project ID | NIH-11263480 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations affecting synaptic functions or those experiencing early signs of degenerative neurological disorders.
✕Less likely to help
Patients with established neurological conditions that do not involve synaptic dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the roles of different protein phosphatase 1 (PP1) isoforms in brain cell functions, particularly in synaptic transmission and memory formation. By using advanced mouse models, the study aims to clarify how these proteins influence the development and function of synapses, which are critical for communication between nerve cells. The researchers will explore the interactions between these proteins and other cellular components to determine their effects on brain health and function.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treatments for degenerative neurological diseases that affect memory and cognitive function.
How similar studies have gone: Previous research has shown promising results in understanding the roles of protein phosphatases in cellular signaling, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Xia, Houhui — University of Rochester
- Study coordinator: Xia, Houhui
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.