Investigating how specific enzymes modify RNA molecules.
Official title: Molecular mechanisms of RNA methyltransferases.
Funded at Boston University Medical Campus · NIH-10938747 · Data updated 2026-11-12
This study is looking at how two special enzymes that change RNA work and how they might be linked to health issues like cancer and heart problems, so that we can better understand these conditions and help patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $246,500 |
| NIH project number | 1R35GM155301-01 |
| Project ID | NIH-10938747 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by cancers, cardiovascular abnormalities, or cognitive impairments.
✕Less likely to help
Patients with conditions unrelated to RNA modifications or those not affected by the diseases being studied may not benefit from this research.
What this research studies
This research focuses on understanding the structure and function of two important enzymes that modify RNA, known as RNA methyltransferases. By exploring how these enzymes work and how they are regulated, the research aims to uncover their roles in various biological processes and diseases. Patients may benefit from insights into how defects in RNA modifications can lead to conditions like cancer, cardiovascular issues, and cognitive impairments. The research employs advanced biochemical techniques to analyze these enzymes and their interactions with RNA.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to RNA modification defects.
How similar studies have gone: Previous research has shown promising results in understanding RNA modifications and their implications in various diseases, indicating that this approach has potential for success.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Dempsey, Daniel R. — Boston University Medical Campus
- Study coordinator: Dempsey, Daniel R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.