Investigating how specific changes in cell translation affect long-term memory storage
Official title: Cell specific & compartment specific changes in translation during long term memory storage
Funded at University of Florida · NIH-11070572 · Data updated 2026-11-12
This study is looking at how nerve cells in a sea slug help store memories by moving important materials around, which could help us understand memory problems in diseases like Alzheimer's.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | January 3, 2025 |
| Project end | January 2, 2028 |
| Funding year | 2025 |
| Award (this year) | $35,974 |
| NIH project number | 1F31MH139249-01 |
| Project ID | NIH-11070572 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting memory or cognitive function, particularly those related to neurodegenerative diseases.
✕Less likely to help
Patients with acute memory loss due to non-neurodegenerative causes may not benefit from this research.
What this research studies
This research explores the intricate processes of translation and transcription in neurons that are crucial for long-term memory storage. By focusing on the model organism Aplysia californica, the study aims to uncover how localized translation in different parts of the neuron influences memory retention. The research will examine the role of molecular motors, such as kinesin and dynein, in transporting essential materials within neurons, which is vital for maintaining synaptic function. Understanding these mechanisms could provide insights into neurodegenerative diseases linked to disruptions in these processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing memory retention and addressing memory-related disorders.
How similar studies have gone: Previous studies have shown promising results in understanding the role of localized translation in neuronal function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Zhao, Yibo — University of Florida
- Study coordinator: Zhao, Yibo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.