Investigating how serotonin affects brain development and plasticity during critical growth periods.
Cell-type Specific Roles for H3 Serotonylation During Critical Periods of Postnatal Brain Development and Plasticity
This study is looking at how serotonin, a chemical in the brain, helps with brain development and changes, especially during important growth periods, and it aims to understand how this affects mood and behavior as we grow up.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11075552 on NIH RePORTER |
What this research studies
This research explores the role of serotonin in brain development and plasticity, particularly focusing on a specific chemical modification called H3 serotonylation. By studying mouse models, the researchers aim to understand how serotonin interacts with brain cells during critical periods of postnatal development and how environmental factors may influence this process. The study employs advanced techniques to analyze changes in gene expression linked to serotonin's effects on different cell types in the brain. This could provide insights into how serotonin impacts mood and behavior during adolescence and adulthood.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 12 years and older who may be experiencing mood or affective disorders.
Not a fit: Patients with no history of mood or affective disorders or those outside the age range of 12 years and older may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new understanding and treatments for mood and stress-related disorders in young people and adults.
How similar studies have performed: While the specific approach of studying H3 serotonylation in this context is novel, related research has shown that serotonin plays a crucial role in brain development and function.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Cunningham, Ashley — Icahn School of Medicine at Mount Sinai
- Study coordinator: Cunningham, Ashley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.