Investigating how SAP97 affects brain function and schizophrenia.
Official title: Uncovering the role of SAP97 in synaptic function and schizophrenia.
Funded at University of Southern California · NIH-11087665 · Data updated 2026-11-12
This study is looking at a protein called SAP97 in the brain to see how it affects communication between brain cells, which might help us understand more about schizophrenia and why it happens.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | June 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $455,016 |
| NIH project number | 5R01NS130185-03 |
| Project ID | NIH-11087665 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with schizophrenia or those at risk of developing the disorder.
✕Less likely to help
Patients with other psychiatric disorders unrelated to schizophrenia may not benefit from this research.
What this research studies
This research explores the role of a protein called SAP97 in the brain's synaptic function, particularly in relation to schizophrenia. It aims to understand how disruptions in SAP97 can lead to increased neuronal activity and glutamatergic transmission in the hippocampus, which may contribute to the development of schizophrenia. The study will utilize advanced imaging and electrophysiological techniques to examine the specific functions of SAP97 in regulating neurotransmission and synaptic plasticity. By uncovering these mechanisms, the research seeks to provide insights into the biological underpinnings of schizophrenia.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating schizophrenia by targeting synaptic dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding synaptic mechanisms in schizophrenia, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Herring, Bruce — University of Southern California
- Study coordinator: Herring, Bruce
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.