Investigating how obstructive sleep apnea affects insulin resistance due to low oxygen levels.
Tissue-Specific Insulin Resistance in Obstructive Sleep Apnea: Role of Hypoxia
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10693797
This study is looking at how obstructive sleep apnea (OSA) affects insulin resistance, especially in people who have low oxygen levels while they sleep, to see how this might lead to issues like type 2 diabetes and fatty liver disease. If you have OSA, this research could help us understand how your sleep condition impacts your overall health and insulin sensitivity.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10693797 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the relationship between obstructive sleep apnea (OSA) and insulin resistance, particularly in patients experiencing low oxygen levels during sleep. The study aims to explore how OSA contributes to conditions like type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) by examining the effects of hypoxia on insulin sensitivity in various tissues, including the liver and adipose tissue. By comparing patients with OSA who experience hypoxia to those who do not, the research seeks to identify specific mechanisms that worsen insulin resistance. Participants may undergo assessments related to their sleep patterns, metabolic health, and tissue responses to better understand these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with obstructive sleep apnea, particularly those experiencing episodes of low oxygen levels during sleep.
Not a fit: Patients without obstructive sleep apnea or those who do not experience hypoxia during sleep may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with obstructive sleep apnea, potentially reducing their risk of developing diabetes and liver disease.
How similar studies have performed: Previous studies have indicated a connection between sleep apnea and insulin resistance, suggesting that this research builds on established findings rather than exploring an entirely novel approach.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHWARZ, JEAN-MARC — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: SCHWARZ, JEAN-MARC
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: non-alcohol fatty liver disease, non-alcoholic liver disease, nonalcoholic fatty liver disease, non-alcoholic fatty liver disease