Investigating how nucleosomes affect gene expression in cells
Official title: Time-resolved chromatin accessibility by Single-Molecule FRET of +1 Nucleosome Dynamics
Funded at Johns Hopkins University · NIH-10998135 · Data updated 2026-11-12
This study is looking at how tiny structures in our cells, called nucleosomes, move around and affect how genes are turned on or off, helping us understand more about how our genes work together to keep our bodies functioning properly.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31GM156098-01 |
| Project ID | NIH-10998135 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals interested in the molecular mechanisms of gene regulation and their potential implications for health.
✕Less likely to help
Patients with conditions unrelated to gene expression or chromatin dynamics may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the dynamic positioning of nucleosomes, which are structures that package DNA in cells, and how they influence gene expression. By using advanced techniques like Single-Molecule FRET, the study aims to observe the real-time movements of nucleosomes at gene promoters, which are crucial for initiating transcription. The goal is to uncover the mechanisms by which various chromatin remodeling enzymes work together to regulate gene activity, providing insights into cellular function and gene regulation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, which may have implications for treating various diseases.
How similar studies have gone: Previous research has shown success in understanding chromatin dynamics, but this specific approach using real-time monitoring of nucleosome positioning is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Yamadi, Maryam — Johns Hopkins University
- Study coordinator: Yamadi, Maryam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.