Investigating how metabolic pathways affect heart function and failure
Metabolic pathways in cardiac physiology and heart failure
This study is looking at how a substance called glutamine affects heart health and heart failure, with the goal of finding new ways to help people with heart problems feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11058850 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of glutamine metabolism in cardiac health and heart failure. It examines how changes in cardiac metabolism and fuel utilization contribute to heart failure, particularly through the production of glutamine in heart muscle cells. By using advanced models, the research aims to uncover the mechanisms by which glutamine affects heart function and fibrosis, potentially leading to new therapeutic strategies for heart failure patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure or those at risk of developing heart failure due to metabolic dysfunction.
Not a fit: Patients with non-cardiac related metabolic disorders or those without heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the progression of heart failure.
How similar studies have performed: Previous research has shown promising results in understanding metabolic pathways in heart failure, indicating that this approach could yield significant insights.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Elrod, John William — Temple Univ of the Commonwealth
- Study coordinator: Elrod, John William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.