Investigating how metabolic pathways affect heart function and failure
Official title: Metabolic pathways in cardiac physiology and heart failure
Funded at Temple Univ of the Commonwealth · NIH-11058850 · Data updated 2026-11-12
This study is looking at how a substance called glutamine affects heart health and heart failure, with the goal of finding new ways to help people with heart problems feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $772,808 |
| NIH project number | 1R01HL172926-01A1 |
| Project ID | NIH-11058850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure or those at risk of developing heart failure due to metabolic dysfunction.
✕Less likely to help
Patients with non-cardiac related metabolic disorders or those without heart failure may not benefit from this research.
What this research studies
This research focuses on understanding the role of glutamine metabolism in cardiac health and heart failure. It examines how changes in cardiac metabolism and fuel utilization contribute to heart failure, particularly through the production of glutamine in heart muscle cells. By using advanced models, the research aims to uncover the mechanisms by which glutamine affects heart function and fibrosis, potentially leading to new therapeutic strategies for heart failure patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the progression of heart failure.
How similar studies have gone: Previous research has shown promising results in understanding metabolic pathways in heart failure, indicating that this approach could yield significant insights.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Elrod, John William — Temple Univ of the Commonwealth
- Study coordinator: Elrod, John William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.