Investigating how long non-coding RNAs help activate genes
Official title: Structural and Functional Studies of lncRNAs in Gene Activation
Funded at Drexel University · NIH-11030832 · Data updated 2026-11-12
This study is looking at how certain RNA molecules, called long non-coding RNAs, help turn on genes that can affect cancer, with the hope of finding new ways to diagnose or treat diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $330,949 |
| NIH project number | 5R01GM149780-03 |
| Project ID | NIH-11030832 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or other diseases where long non-coding RNAs are known to be dysregulated.
✕Less likely to help
Patients with conditions unrelated to lncRNA dysregulation or those not diagnosed with cancer may not benefit from this research.
What this research studies
This research focuses on understanding the role of long non-coding RNAs (lncRNAs) in the activation of genes, particularly through their interaction with the SWI/SNF complex, which is important for gene regulation and is known to be involved in cancer. The study aims to uncover the molecular mechanisms by which lncRNAs influence transcription and how they may serve as biomarkers or therapeutic targets in diseases. By utilizing advanced sequencing technologies and biochemical assays, the researchers will explore the interactions between lncRNAs and epigenetic machinery to gain insights into their functions in cellular processes and disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new biomarkers and therapeutic strategies for various cancers and other diseases linked to lncRNA dysregulation.
How similar studies have gone: Other research has shown promising results in understanding the role of lncRNAs in gene regulation, indicating that this approach has potential for significant findings.
Where this research is happening
-
Drexel University
Philadelphia, United States Active
Researchers
- Principal investigator: Somarowthu, Srinivas — Drexel University
- Study coordinator: Somarowthu, Srinivas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.