Investigating how kinase dysfunction affects autism and neurodevelopmental disorders
Kinase Dysfunction in Autism and Neurodevelopmental Disorders
This study is looking at a protein called TAOK1 to see how changes in it might affect brain development in people with autism and other related conditions, hoping to find helpful information that could improve understanding and treatment for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11017047 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein kinase, TAOK1, in the development of autism spectrum disorder and other neurodevelopmental disorders. By examining how mutations in TAOK1 affect neuronal growth and function, the researchers aim to uncover the mechanisms behind these conditions. The study employs advanced techniques such as proteomics, chemical genetics, and stem cell technology to explore how TAOK1 interacts with neuronal membranes and influences neuronal morphology. Patients may benefit from insights gained into the biological processes underlying their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autism spectrum disorder or other neurodevelopmental disorders, particularly those with known mutations in the TAOK1 gene.
Not a fit: Patients without neurodevelopmental disorders or those not carrying mutations in the TAOK1 gene may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autism and related neurodevelopmental disorders.
How similar studies have performed: Previous research has indicated a critical role of kinase dysfunction in neurodevelopmental disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Yadav, Smita — University of Washington
- Study coordinator: Yadav, Smita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.