Investigating how immune cells affect migraine treatments using CGRP.
The role of meningeal immune cells in the efficacy of CGRP-based migraine therapies
This study is looking at how certain immune cells in the brain might affect how well new migraine treatments work, especially for those who experience migraine auras, to help find better ways to relieve migraine pain for patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11001228 on NIH RePORTER |
What this research studies
This research explores the relationship between immune cell activation and the effectiveness of CGRP-based therapies for migraines. It focuses on how cortical spreading depression (CSD), which can trigger migraine auras, activates meningeal macrophages that may contribute to migraine pain. By analyzing the role of these immune cells and their interaction with CGRP signaling, the study aims to uncover mechanisms that could enhance migraine treatment. Patients may benefit from a better understanding of how these therapies work and potentially improved treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic migraines, particularly those who experience aura.
Not a fit: Patients who do not suffer from migraines or have other neurological disorders unrelated to migraine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective migraine treatments by targeting immune cell interactions.
How similar studies have performed: Previous research has shown promising results in understanding the role of CGRP in migraine therapies, indicating that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Adi, Talia — University of Pittsburgh at Pittsburgh
- Study coordinator: Adi, Talia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.