Investigating how human-specific genetic sequences affect brain development and autism.
Human-specific splicing regulation in neurogenesis and disease
This study is looking at how certain unique genetic sequences might affect brain development and their connection to autism, with the hope of finding new ways to help people with autism spectrum disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10947154 on NIH RePORTER |
What this research studies
This research explores the role of unique human genetic sequences in the development of the brain and their potential link to autism. By examining how these sequences influence the regulation of gene splicing, the study aims to uncover mechanisms that may contribute to neurodevelopmental disorders. The research will involve testing specific genetic variations associated with autism to understand their impact on brain function and development. Patients may benefit from insights that could lead to new therapeutic approaches for autism spectrum disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation would be children aged 0-11 years, particularly those diagnosed with autism spectrum disorder.
Not a fit: Patients who are older than 11 years or do not have autism spectrum disorder may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into the genetic factors contributing to autism, potentially leading to improved treatments and interventions.
How similar studies have performed: Other research has shown promising results in understanding genetic influences on neurodevelopment, suggesting that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Moss, Nicole D — Duke University
- Study coordinator: Moss, Nicole D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.