Investigating how genetic risks for autism affect brain cell interactions
Functional Genomic Interrogation of Autism Spectrum Disorder Genetic Risk on Microglia-Neuronal Interactions
This study is looking at how certain genes linked to autism spectrum disorder (ASD) affect the way brain cells interact during development, using special lab-grown brain models to help us understand more about ASD and what causes it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10999203 on NIH RePORTER |
What this research studies
This research explores the genetic factors contributing to autism spectrum disorder (ASD) by examining how these factors influence interactions between microglia and neurons in the developing brain. Using advanced human stem cell technology, the study will create three-dimensional models of human brain development to analyze the effects of specific ASD-related genetic mutations. By studying these interactions, researchers aim to uncover the role of microglia, a type of brain cell, in the development of ASD. This could lead to a better understanding of the disorder and its underlying mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a diagnosis of autism spectrum disorder, particularly those with known genetic mutations associated with the condition.
Not a fit: Patients without a diagnosis of autism or those whose condition is not linked to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into the biological mechanisms of autism, potentially leading to new therapeutic strategies.
How similar studies have performed: Previous research has shown promising results in understanding genetic influences on autism, but this specific approach using 3D models is relatively novel.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hawken, Natalie — University of California Los Angeles
- Study coordinator: Hawken, Natalie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.