Investigating how FOXK proteins affect KSHV infection
Official title: Role of FOXK subfamily in KSHV infection
Funded at University of Florida · NIH-10997917 · Data updated 2026-11-12
This study is looking at how certain proteins called FOXK help the Kaposi's sarcoma-associated herpesvirus (KSHV) behave, which could lead to better ways to treat diseases linked to this virus, like Kaposi's sarcoma.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | August 16, 2024 |
| Project end | August 15, 2027 |
| Funding year | 2024 |
| Award (this year) | $44,982 |
| NIH project number | 1F31DE034303-01 |
| Project ID | NIH-10997917 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by KSHV-related diseases, such as Kaposi's sarcoma or primary effusion lymphoma.
✕Less likely to help
Patients who do not have KSHV-related diseases or are not infected with KSHV may not benefit from this research.
What this research studies
This research focuses on understanding the role of FOXK proteins in the lifecycle of Kaposi's sarcoma-associated herpesvirus (KSHV), which is linked to several diseases including Kaposi's sarcoma. The study will explore how these proteins interact with KSHV's immediate early proteins during the virus's lytic reactivation phase. By using advanced techniques such as co-immunoprecipitation and imaging analysis, researchers aim to identify the mechanisms by which FOXK proteins influence KSHV infection and its associated diseases. This could lead to new insights into potential therapeutic targets for managing KSHV-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for diseases associated with KSHV, improving patient outcomes.
How similar studies have gone: While the specific role of FOXK proteins in KSHV infection is not well-studied, similar research approaches have shown promise in understanding viral interactions with host cellular mechanisms.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Palmer, Marley — University of Florida
- Study coordinator: Palmer, Marley
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.