Investigating how enzymes work using advanced electron imaging techniques
Official title: Emergent Technology for Studying the Structure/Function Relationship of Enzymes Using Electron Paramagnetic Resonance
Funded at Medical College of Wisconsin · NIH-11058434 · Data updated 2026-11-12
This study is looking at how certain proteins called enzymes work in the body by using a special technique to see how they interact with their surroundings, which could help improve medical tests and treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | June 9, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $327,600 |
| NIH project number | 5R01GM149568-03 |
| Project ID | NIH-11058434 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve enzyme deficiencies or malfunctions.
✕Less likely to help
Patients with conditions unrelated to enzyme function may not receive any benefit from this research.
What this research studies
This research focuses on using electron paramagnetic resonance (EPR) to study enzymes, which are proteins that facilitate chemical reactions in the body. By measuring the energy absorption of unpaired electrons, researchers can gain insights into how these enzymes interact with their environment and function at a molecular level. The project aims to enhance EPR techniques to improve sensitivity and accuracy, allowing for better understanding of enzyme behavior in various conditions. This could lead to advancements in clinical diagnostics and therapeutic development.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatments for conditions related to enzyme dysfunction.
How similar studies have gone: Previous research using EPR techniques has shown promise in understanding enzyme mechanisms, indicating potential for success in this approach.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Sidabras, Jason W — Medical College of Wisconsin
- Study coordinator: Sidabras, Jason W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.