Investigating how deep brain stimulation affects white matter in the brain
Establishing the anatomical and functional mechanisms of white matter deep brain stimulation
This study is looking at a new way to use deep brain stimulation to help people with tough-to-treat neurological or mental health issues by focusing on the brain's white matter, and researchers are testing this on macaques to see how it affects mood and emotions over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10928228 on NIH RePORTER |
What this research studies
This research explores a new approach to deep brain stimulation (DBS) that targets white matter in the brain rather than specific areas. By studying macaques, the researchers aim to understand how stimulating certain white matter tracts can influence brain activity and potentially improve symptoms in individuals with treatment-resistant neurological or psychiatric disorders. The study will analyze both immediate and long-term effects of this stimulation on mood and emotional states, providing insights into the underlying mechanisms of this therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from treatment-resistant neurological or psychiatric disorders, particularly those with severe mood disorders.
Not a fit: Patients with mild mood disorders or those who respond well to conventional treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with severe mood disorders who do not respond to traditional therapies.
How similar studies have performed: While deep brain stimulation has been used in various contexts, this specific approach targeting white matter is relatively novel and has not been extensively tested in prior research.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Rudebeck, Peter — Icahn School of Medicine at Mount Sinai
- Study coordinator: Rudebeck, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.