Investigating how chromosome proteins evolve alongside DNA changes
Official title: Causes and consequences of intra-genomic coevolution
Funded at University of Pennsylvania · NIH-10873127 · Data updated 2026-11-12
This study is looking at how certain proteins in fruit flies change when they interact with DNA, using a special tool called CRISPR to create small genetic changes, and the findings could help us understand more about chromosomes and potentially lead to better treatments for genetic disorders.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $122,747 |
| NIH project number | 5K99GM149943-02 |
| Project ID | NIH-10873127 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders related to chromosome abnormalities or those interested in the genetic basis of diseases.
✕Less likely to help
Patients with non-genetic conditions or those not affected by chromosome-related issues may not receive any benefit from this research.
What this research studies
This research explores the relationship between rapidly evolving chromosomal proteins and the DNA sequences they interact with, particularly in the fruit fly Drosophila. By using CRISPR/Cas9 technology, the study aims to create specific genetic mismatches that can reveal how these proteins adapt to changes in DNA. This approach will help to uncover the mechanisms behind chromosome integrity and function, which are crucial for understanding various genetic conditions. Patients may benefit from insights gained about chromosome biology that could inform future treatments for genetic disorders.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of chromosome-related diseases and potential new therapies for genetic disorders.
How similar studies have gone: Other research has shown success using CRISPR technology to investigate genetic functions, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Brand, Cara — University of Pennsylvania
- Study coordinator: Brand, Cara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.