Investigating how changes in the X chromosome affect cancer differences between sexes
Official title: Probing the role of somatic X-chromosome alterations in shaping cancer sex differences
Funded at Dana-Farber Cancer Inst · NIH-10932213 · Data updated 2026-11-12
This study is looking at how differences in the X chromosome might affect cancer rates in men and women, and it needs patients to help by sharing samples or information to better understand how these genetic changes can influence cancer development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $519,195 |
| NIH project number | 5R01CA286652-02 |
| Project ID | NIH-10932213 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with specific types of cancer, particularly those that show notable differences in incidence between sexes.
✕Less likely to help
Patients with cancers that do not exhibit sex differences or those unrelated to X chromosome alterations may not benefit from this research.
What this research studies
This research explores the genetic factors that contribute to differences in cancer incidence between males and females, focusing specifically on the X chromosome. The study aims to understand how alterations in the X chromosome can influence cancer development in both sexes. By utilizing advanced techniques like CRISPR, researchers will analyze how these genetic changes may lead to either harmful or beneficial gene expression in cancer cells. Patients may be involved in providing samples or data to help uncover these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for cancers that exhibit sex differences.
How similar studies have gone: Other research has shown promising results in understanding genetic factors in cancer, but this specific focus on X chromosome alterations is relatively novel.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Viswanathan, Srinivas Raghavan — Dana-Farber Cancer Inst
- Study coordinator: Viswanathan, Srinivas Raghavan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.