Investigating how certain proteins affect accelerated aging in mice
Official title: Using mouse models to dissect the roles of ZMPSTE24 and prelamin A in accelerated aging
Funded at Columbia University Health Sciences · NIH-10951313 · Data updated 2026-11-12
This study is looking at how certain proteins affect aging in kids with Hutchinson-Gilford progeria syndrome, using specially modified mice to see how changes in a specific gene and protein might speed up aging, which could help us learn more about aging in people.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $82,250 |
| NIH project number | 1R03AG088752-01 |
| Project ID | NIH-10951313 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with accelerated aging disorders such as Hutchinson-Gilford progeria syndrome or mandibuloacral dysplasia.
✕Less likely to help
Patients with typical aging processes or those without genetic mutations related to accelerated aging may not benefit from this research.
What this research studies
This research explores the roles of specific proteins involved in accelerated aging disorders, particularly focusing on conditions like Hutchinson-Gilford progeria syndrome. By using mouse models with genetic modifications, the study aims to understand how mutations in the ZMPSTE24 gene and prelamin A protein contribute to aging processes. The researchers will analyze the effects of these mutations on cellular structures and aging characteristics, providing insights that could lead to better understanding of aging in humans.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing accelerated aging disorders in patients.
How similar studies have gone: Previous research has shown promising results in understanding accelerated aging through genetic studies, indicating that this approach may yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Worman, Howard J — Columbia University Health Sciences
- Study coordinator: Worman, Howard J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.