Investigating how cell-free hemoglobin affects blood vessel function in sepsis
Official title: Cell-Free Hemoglobin Induces Endothelial Mitochondrial Oxidative Damage Causing Extracellular DNA Release
Funded at Vanderbilt University · NIH-10991663 · Data updated 2026-11-12
This study is looking at how a certain type of hemoglobin in the blood affects blood vessel health during sepsis, which is a serious condition that can harm your organs, and it aims to find ways to help critically ill patients feel better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | December 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $26,959 |
| NIH project number | 5F31HL167471-03 |
| Project ID | NIH-10991663 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill patients diagnosed with sepsis or acute respiratory distress syndrome.
✕Less likely to help
Patients who are not critically ill or do not have sepsis may not receive any benefit from this research.
What this research studies
This research explores the impact of oxidized cell-free hemoglobin on blood vessel function during sepsis, a severe condition that can lead to organ failure. The study focuses on understanding how this hemoglobin damages the endothelial cells lining blood vessels, leading to mitochondrial dysfunction and the release of extracellular mitochondrial DNA. By examining these mechanisms, the research aims to uncover potential therapeutic targets to improve outcomes for critically ill patients. Patients may benefit from insights gained about the role of cell-free hemoglobin in sepsis and its effects on vascular health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect blood vessels and improve survival rates in patients with sepsis.
How similar studies have gone: Previous research has indicated that targeting oxidative stress in sepsis may improve patient outcomes, suggesting that this approach could be promising.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Riedmann, Kyle Joseph — Vanderbilt University
- Study coordinator: Riedmann, Kyle Joseph
Related research
Other NIH-funded projects on the same topics.
-
Understanding how peer norms around alcohol and HIV prevention affect adolescents and young adults in rural Uganda
This project studies how what young people think their peers do or approve of influences drinking and HIV prevention behaviors in rural Uganda, with the goal of improving health outcomes.
-
Cancer Pain Management for Asian American Breast Cancer Survivors with Depressive Symptoms
A technology-based program helps Asian American breast cancer survivors with depressive symptoms manage chronic pain more effectively from home using a web app and mobile tools.
-
Targeted gene silencing in the brain using siRNA helpers
This grant tests a new way to turn off specific brain genes in particular CNS cell types using siRNA conjugates to help understand brain biology and disease.
-
RSELVES Study: How older couples influence daily life and function with Alzheimer’s risk
A study to understand how daily routines and support between older adults and their partners relate to the development of Alzheimer’s-related functional decline.
-
Molecular mechanisms of coat assembly and regulation in membrane trafficking
A research project seeks to understand how cellular coats organize and regulate the delivery of membrane-bound cargo, with a focus on proteins related to neurological diseases.
-
Synaptic nanostructure in neurodevelopmental disorders
This project aims to map the tiny architecture of brain synapses in native cells to understand how connections form and change in neurodevelopmental disorders.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.