Investigating how CDCP1 contributes to autoimmune uveitis
Role of CDCP1 in the pathogenesis of autoimmune uveitis
This study is looking at a protein called CDCP1 to see how it affects the movement of harmful T cells in the eye, which could help us find new ways to treat autoimmune uveitis and protect your vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10873898 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of CDCP1, a protein that may influence the development of autoimmune uveitis, a condition that can lead to blindness. The study involves examining how CDCP1 affects the infiltration of harmful T cells through the blood-retina barrier, which is crucial for maintaining eye health. By using specialized techniques and reagents, researchers aim to uncover the mechanisms by which CDCP1 interacts with T cells and impacts retinal cells, potentially leading to new treatment strategies for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune uveitis or those at risk of developing this condition.
Not a fit: Patients with other forms of uveitis not related to autoimmune processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating autoimmune uveitis, potentially reducing the risk of blindness.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in autoimmune diseases, suggesting potential for success in this approach.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Lin, Feng C — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Lin, Feng C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.