Investigating how airway inflammation and fear interact in the brain
Airway inflammation and fear: neuroimmune mechanisms and forebrain circuits
This study is looking at how inflammation in the airways of people with severe asthma might affect how the brain handles fear, which could help us find new treatments for PTSD and similar issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10677767 on NIH RePORTER |
What this research studies
This research explores the connection between airway inflammation, particularly in severe asthma, and fear regulation in the brain, focusing on how these factors contribute to conditions like post-traumatic stress disorder (PTSD). The study examines the role of the prefrontal cortex and specific immune responses in fear dysregulation, using mouse models to understand the underlying mechanisms. By identifying the biological pathways involved, the research aims to uncover potential new treatments for individuals suffering from PTSD and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with severe asthma who also experience symptoms of PTSD or fear dysregulation.
Not a fit: Patients without asthma or those who do not experience fear dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic strategies for managing PTSD and improving mental health in patients with severe asthma.
How similar studies have performed: Previous research has shown promising results in understanding the links between inflammation and mental health, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Sah, Renu — University of Cincinnati
- Study coordinator: Sah, Renu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.