Investigating how a specific receptor affects pancreatic cell changes and cancer development
The CCK-B receptor signaling pathway as a driver of pancreatic cellular plasticity and carcinogenesis
This study is looking at how a specific receptor in the pancreas might affect the way pancreatic cells change when someone has chronic pancreatitis or pancreatic cancer, and it will test a medication called proglumide to see if it can help reduce inflammation and improve cell function for people dealing with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11049099 on NIH RePORTER |
What this research studies
This research focuses on understanding how the cholecystokinin-B receptor (CCK-BR) influences the transformation of pancreatic cells, particularly in the context of chronic pancreatitis and pancreatic cancer. It examines how inflammation can lead to changes in cell types, potentially resulting in cancer. The study involves using a CCK-receptor antagonist, proglumide, to see if it can help restore normal cell function and reduce inflammation in the pancreas. By exploring these mechanisms, the research aims to identify new therapeutic strategies for patients with pancreatic conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with chronic pancreatitis or early-stage pancreatic cancer.
Not a fit: Patients with advanced pancreatic cancer who are not responsive to treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help reverse pancreatic damage and reduce the risk of pancreatic cancer.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting receptor pathways in cancer treatment, suggesting potential for success in this study.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Smith, Jill P — Georgetown University
- Study coordinator: Smith, Jill P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.