Investigating how a specific protein from Staphylococcus aureus affects lung infections.
The Role of Staphylococcus aureus SasD in Lung
This study is looking at how a protein made by a common bacteria can make lung infections worse after the flu, and it hopes to find new ways to help people who are dealing with pneumonia and similar issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10912060 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called SasD produced by Staphylococcus aureus in causing lung infections, particularly after influenza. The researchers will use animal models to explore how SasD contributes to the bacteria's ability to attach to lung cells and provoke inflammation. By examining these interactions, the study aims to uncover new insights into the mechanisms of lung injury and infection, which could lead to better treatment strategies for patients suffering from pneumonia and related complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced pneumonia or lung infections, especially those with a history of influenza.
Not a fit: Patients with lung infections caused by other bacteria or those without a history of respiratory illnesses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve outcomes for patients with lung infections caused by Staphylococcus aureus.
How similar studies have performed: Previous research has shown success in understanding bacterial virulence factors in lung infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Alcorn, John F — University of Pittsburgh at Pittsburgh
- Study coordinator: Alcorn, John F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.