Investigating how a specific immune receptor affects leukemia development
Role of LAM-specific TREM1 in leukemogenesis
This study is looking at how a special immune receptor called TREM1 affects the growth of acute myeloid leukemia (AML) by using mouse models, which could help find new ways to treat this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10975114 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific immune receptor, TREM1, in the development of acute myeloid leukemia (AML). By studying mouse models that mimic leukemia progression, the researchers aim to uncover how TREM1 influences the behavior of macrophages in the tumor microenvironment. The approach involves genetic manipulation to observe the effects of TREM1 deletion in macrophages on leukemia progression. This could provide insights into new therapeutic strategies targeting immune responses in leukemia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia or those at risk of developing it due to genetic factors.
Not a fit: Patients with other types of cancer or those without a genetic predisposition to leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with acute myeloid leukemia.
How similar studies have performed: Previous research has shown promising results in targeting immune responses in cancer, suggesting that this approach may yield significant insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Du, Wei — University of Pittsburgh at Pittsburgh
- Study coordinator: Du, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.