Investigating gene expression patterns in early childhood development
Official title: Penn-DISAM: Data Integration and Statistical Analysis Methods for dGTEx Data
Funded at University of Pennsylvania · NIH-10990746 · Data updated 2026-11-12
This study is looking at how genes behave in the brain and other tissues as kids grow up, using data from both humans and monkeys, to help us understand how age and different body parts affect gene activity, which could give us important clues about development and health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 19, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,921,885 |
| NIH project number | 1U01HG013841-01 |
| Project ID | NIH-10990746 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years, particularly those with developmental concerns or conditions.
✕Less likely to help
Patients outside the age range of 0-11 years or those without developmental issues may not benefit from this research.
What this research studies
This research focuses on understanding how gene expression patterns in various tissues, particularly in the brain, change during early childhood development. By analyzing data from both human and non-human primate models, the project aims to develop new statistical and computational methods to effectively interpret complex gene expression data. This could help identify how age and tissue type influence gene activity, which is crucial for understanding developmental biology and potential health risks. The research utilizes advanced computational tools to analyze large datasets, providing insights into the biological processes that occur during critical developmental windows.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of childhood development and potential interventions for developmental disorders.
How similar studies have gone: Previous research in developmental biology has shown success in understanding gene expression patterns, making this approach promising yet innovative.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Lee, Hongzhe — University of Pennsylvania
- Study coordinator: Lee, Hongzhe
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.