Investigating bile acids and their role in metabolic surgery
Bile acids and metabolic surgery
['FUNDING_R01'] · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · NIH-10843940
This study is looking at how a type of weight-loss surgery called vertical sleeve gastrectomy affects bile acids in the body, with the goal of finding safer and cheaper ways to help people with obesity and type 2 diabetes feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BECKMAN RESEARCH INSTITUTE/CITY OF HOPE (nih funded) |
| Locations | 1 site (DUARTE, UNITED STATES) |
| Trial ID | NIH-10843940 on ClinicalTrials.gov |
What this research studies
This research explores how bile acids are affected by bariatric surgery, specifically vertical sleeve gastrectomy (VSG), and aims to understand the molecular mechanisms that lead to improvements in obesity and type 2 diabetes. By studying changes in bile acid composition and related enzymes in a mouse model, the research seeks to identify safer and more affordable treatment options for metabolic diseases. The findings could help develop new therapies that mimic the benefits of surgery without the associated risks and costs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from obesity, type 2 diabetes, or non-alcoholic fatty liver disease, particularly those who may not have access to bariatric surgery.
Not a fit: Patients who are not affected by obesity, type 2 diabetes, or related metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative, cost-effective treatments for obesity and type 2 diabetes that are accessible to a broader population.
How similar studies have performed: Previous research has shown promising results in understanding the metabolic benefits of bariatric surgery, suggesting that this approach could yield valuable insights.
Where this research is happening
DUARTE, UNITED STATES
- BECKMAN RESEARCH INSTITUTE/CITY OF HOPE — DUARTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, WENDONG — BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- Study coordinator: HUANG, WENDONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: non-alcoholic fatty liver disease, non-alcohol fatty liver disease, non-alcoholic liver disease, nonalcoholic fatty liver disease, fatty liver disease