Investigating a new ribonuclease in bacteria
Official title: YloC, a new ribonuclease of Bacillus subtilis
Funded at Icahn School of Medicine at Mount Sinai · NIH-11075794 · Data updated 2026-11-12
This study is looking at a special protein in bacteria that helps break down messages in their cells, and by changing parts of this protein, researchers hope to learn more about how it works, which could help in creating new antibiotics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $354,900 |
| NIH project number | 5R01GM147211-03 |
| Project ID | NIH-11075794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with bacterial infections that are resistant to current treatments.
✕Less likely to help
Patients with viral infections or non-bacterial conditions are unlikely to benefit from this research.
What this research studies
This research focuses on understanding a newly identified ribonuclease called YloC in the bacterium Bacillus subtilis, which plays a crucial role in the decay of messenger RNA (mRNA). The researchers will use various biochemical techniques to explore how YloC interacts with RNA and its structural properties. By mutating specific parts of the YloC protein, they aim to determine how these changes affect its function and ability to bind RNA. This work could provide insights into bacterial RNA processes and potentially inform antibiotic design.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for developing antimicrobial agents targeting bacterial RNA processes.
How similar studies have gone: While the specific investigation of YloC is novel, similar approaches in studying ribonucleases have shown promise in understanding bacterial RNA decay mechanisms.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Bechhofer, David H — Icahn School of Medicine at Mount Sinai
- Study coordinator: Bechhofer, David H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.