InterACT: Defining ARDS patient subtypes to guide future treatments
Official title: The Intermountain West-Atlantic Center (InterACT) for the APS Phenotyping Consortium
Funded at Ihc Health Services, INC. · NIH-11325740 · Data updated 2026-11-12
A national collaboration will analyze blood markers and clinical data from adults with ARDS, pneumonia, and sepsis to identify patient subtypes that might respond differently to therapies.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ihc Health Services, INC. NIH-funded |
| Lab location | 1 site (Salt Lake City, UNITED STATES) |
| Project start | May 1, 2023 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $654,660 |
| NIH project number | 5U01HL168416-04 |
| Project ID | NIH-11325740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with ARDS, pneumonia, or sepsis who are cared for at participating sites and have available biomarker data.
✕Less likely to help
Patients without ARDS, pneumonia, or sepsis or those not treated at participating sites may not benefit.
What this research studies
InterACT brings together four sites to apply advanced statistics and machine learning to classify ARDS and related conditions into meaningful patient phenotypes. The project will use multiplex cytokine panels and clinical data, accounting for treatments patients receive, to improve phenotype accuracy. Findings will be checked in simulated trials to explore potential therapeutic implications, including tissue injury biomarkers like hyaluronan and sRAGE. The aim is to pave the way for treatment-responsive subgroups that could be targeted in future real clinical trials.
Why it matters
Potential benefit: If successful, patients with ARDS or related infections could receive more personalized therapies based on their phenotype.
How similar studies have gone: Previous phenotyping efforts have shown promise in guiding trials, but this project aims to validate and extend those approaches with new biomarkers and emulated trials.
Where this research is happening
-
Ihc Health Services, INC.
Salt Lake City, United States Active
Researchers
- Principal investigator: Brown, Samuel Morris — Ihc Health Services, INC.
- Study coordinator: Brown, Samuel Morris
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.