Integrated knowledge resource for the human pancreas and Type 1 diabetes
Official title: An interactive resource to generate and provide integrated knowledge of the human pancreas
Funded at University of California, San Diego · NIH-11614074 · Data updated 2026-11-12
A large NIH grant aims to build a comprehensive, user-friendly knowledge base that combines many data about the human pancreas to help understand and treat Type 1 diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | February 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $5,545,581 |
| NIH project number | 4U24DK138512-04 |
| Project ID | NIH-11614074 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with Type 1 diabetes or brittle diabetes who contribute samples or clinical data to related studies, or who may benefit from future biomarker discoveries arising from this resource.
✕Less likely to help
Purely basic data integration work without direct patient involvement would not provide immediate benefit to individual patients.
What this research studies
This project will create PanKbase, a centralized database that harmonizes and shares data from human pancreas studies to illuminate how Type 1 diabetes starts and progresses. Researchers will use advanced computational tools to integrate disparate datasets, make them accessible, and support analyses that could reveal new biomarkers and therapeutic targets. The effort involves collaboration among leaders in diabetes biology, immunology, and data science, with a focus on rigor and reproducibility. By making deep, integrated pancreatic data available to researchers, the work aims to accelerate discoveries that could eventually benefit patients with brittle or type 1 diabetes.
Why it matters
Potential benefit: Patients could benefit from faster discovery of biomarkers and new therapeutic targets for Type 1 diabetes through improved data sharing and analysis.
How similar studies have gone: Similar large-scale, data-hub projects in other diseases have accelerated biomarker discovery and cross-study analyses when data are harmonized and widely accessible.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Gaulton, Kyle Jeffrie — University of California, San Diego
- Study coordinator: Gaulton, Kyle Jeffrie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.