Innovative methods to improve brain function in Parkinson's disease
Circuit-Inspired Strategies to Restore Basal Ganglia Function in Mouse Models of Parkinson’s Disease
This study is looking at how certain brain cells in a part of the brain affected by Parkinson's disease can be targeted to help improve movement and reduce symptoms, with the goal of creating better treatments for people living with the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie-Mellon University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11109639 on NIH RePORTER |
What this research studies
This research investigates how specific neurons in the globus pallidus, a part of the brain affected in Parkinson's disease, can be targeted to restore normal function. By using advanced techniques like optogenetics and deep brain stimulation, the study aims to develop new treatment protocols that could provide longer-lasting relief from motor symptoms. The approach focuses on understanding the different roles of neuron types in the globus pallidus and how they can be manipulated to improve patient outcomes. Collaborations with neurosurgeons will help translate these findings into potential therapies for human patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who experience motor symptoms.
Not a fit: Patients with Parkinson's disease who do not respond to deep brain stimulation or have other complicating health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Parkinson's disease, significantly improving motor function and quality of life for patients.
How similar studies have performed: Previous research has shown promising results with deep brain stimulation techniques, suggesting that this novel approach could also be effective.
Where this research is happening
Pittsburgh, United States
- Carnegie-Mellon University — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Gittis, Aryn Hilary — Carnegie-Mellon University
- Study coordinator: Gittis, Aryn Hilary
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.