In-home HEPA filtration to slow biological aging and improve heart and lung health in older adults with eosinophilic COPD

Who could benefit from this research

What this research studies

This study builds on a randomized, double-blind trial that places HEPA filters or sham devices in homes of former smokers with eosinophilic COPD for one year. Researchers will measure aging-related molecular changes in nasal tissue and blood, along with cardiopulmonary health indicators, to see if cleaner air slows aging at a biological level. The approach combines epigenetic and proteomic analyses with clinical assessments to understand how reducing indoor particulate exposure affects aging and disease risk in a high-risk population. Participants will continue to receive follow-up visits and sample collection as part of the parent trial at NIEHS. Overall, the project seeks to link real-world air quality improvements to tangible biological and health benefits for older adults with COPD.

Why it matters

Where this research is happening

• Stanford University
  Stanford, United States Active

Researchers

• Principal investigator: Cardenas, Andres — Stanford University
• Study coordinator: Cardenas, Andres

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.