Improving wound healing through advanced tissue engineering techniques
Official title: Vasculogenic Regenerative Medicine Technology
Funded at University of Pittsburgh at Pittsburgh · NIH-11021358 · Data updated 2026-11-12
This study is exploring a new way to help wounds heal faster by using a special technique to turn skin cells into ones that can help grow new blood vessels right at the injury site, which could lead to better recovery for patients with acute wounds.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | December 10, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $543,826 |
| NIH project number | 1R01DK141513-01 |
| Project ID | NIH-11021358 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with acute wounds that are experiencing delayed healing.
✕Less likely to help
Patients with chronic wounds or those not responding to standard wound care may not benefit from this research.
What this research studies
This research investigates innovative methods to enhance wound healing by utilizing a technique called tissue nanotransfection (TNT) to convert skin fibroblasts into vasculogenic fibroblasts. By applying specific transcription factors, the study aims to promote the formation of new blood vessels directly at the wound site, potentially improving recovery from acute wounds. The approach focuses on understanding the biological processes that enable this transformation and how it can be effectively applied in vivo. Patients may benefit from improved healing outcomes through this advanced regenerative medicine technology.
Why it matters
Potential benefit: If successful, this research could lead to faster and more effective healing of acute wounds, reducing complications and improving quality of life for patients.
How similar studies have gone: Previous studies have shown promising results using similar tissue engineering approaches, indicating potential for success in this novel application.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Sen, Chandan K — University of Pittsburgh at Pittsburgh
- Study coordinator: Sen, Chandan K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.