Improving survival rates after cardiac arrest using new techniques
Official title: Head Up CPR and Aortic Occlusion to Improve Survival after Refractory Cardiac Arrest
Funded at Advancedcpr Solutions LLC · NIH-11067147 · Data updated 2026-11-12
This study is looking at new ways to help people who have a cardiac arrest and don’t respond to regular CPR, using a special technique that keeps blood flowing to important organs, to see if it can improve their chances of survival.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Advancedcpr Solutions LLC NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | January 1, 2025 |
| Project end | January 2, 2025 |
| Funding year | 2025 |
| Award (this year) | $1 |
| NIH project number | 1R43HL177950-01 |
| Project ID | NIH-11067147 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing refractory cardiac arrest who have not responded to standard resuscitation efforts.
✕Less likely to help
Patients who are not experiencing cardiac arrest or those who have already received successful resuscitation will not benefit from this research.
What this research studies
This research investigates innovative methods to enhance survival rates for patients experiencing refractory cardiac arrest, a condition where standard resuscitation techniques fail. The approach involves the use of head-up CPR combined with aortic occlusion to improve blood flow and oxygen delivery to vital organs during cardiac arrest. By focusing on patients who do not respond to conventional CPR and defibrillation, the study aims to develop a more effective treatment strategy. Patients will be monitored closely to assess the effectiveness of these new techniques in real-time.
Why it matters
Potential benefit: If successful, this research could significantly increase survival rates and improve outcomes for patients suffering from refractory cardiac arrest.
How similar studies have gone: While there have been limited successes with similar approaches, this research aims to explore a novel combination of techniques that have not been widely tested together.
Where this research is happening
-
Advancedcpr Solutions LLC
Minneapolis, United States Active
Researchers
- Principal investigator: Lurie, Keith — Advancedcpr Solutions LLC
- Study coordinator: Lurie, Keith
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
-
Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
-
Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
-
Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
-
Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.